OPKO Health Inc

NASDAQ:OPK

Earnings Call Analysis

OPKO Health Earnings Call: Progress and Projections

OPKO Health celebrated significant achievements in 2023, expecting continued progress in 2024. The FDA approved NGENLA, OPKO's growth hormone therapy, now launched in over 40 markets, addressing a $5.5 billion market. Partnerships with BARDA and Merck are advancing OPKO's pipeline, with funds to support the development against various viral threats and a vaccine candidate targeting the Epstein-Barr virus. Sales of RAYALDEE grew by 13%, and a new oxyntomodulin formulation for diabetes and obesity is being evaluated preclinically. Although BioReference's diagnostics segment faced a revenue decline, the company is focused on returning to profitability and lowering cash burn expectations for operating cash flow in 2024 to between $40 million and $60 million. Revenue in Q4 2023 increased to $57.7 million, and the company guides a full-year gross profit share from Pfizer of $40 million to $50 million for 2024.

OPKO Eagerly Anticipates 2024 Following Strong 2023 Achievements

Optism greets the year for OPKO as 2023 milestones set the stage for continued growth. Fueled by FDA approval of their growth hormone therapy NGENLA and bolstered by Pfizer's global launch, OPKO eyes a larger slice of the lucrative $5.5 billion market.

Strategic Alliances Propel OPKO's ModeX into Prominence

ModeX leaps ahead with crucial partnerships, including a license and collaboration with pharma giant Merck to combat Epstein-Barr virus, and a notable contract with BARDA, equipping them to fend off potent public health threats like COVID-19 and potentially influenza.

RAYALDEE Sales Growth and Optimism for Diabetes Treatment

RAYALDEE enjoys a 13% sales jump in its battle against chronic kidney disease, while optimism is cautiously renewed for OPKO's promising treatment for Type 2 diabetes and obesity, pending positive preclinical evaluations.

Subsidiaries and BioReference Health Fortify OPKO's Financial Health

A diverse portfolio including OPKO Iberoamerica, FinTech, and EirGen coupled with restructuring aims, indicate a sharp focus on returning BioReference Health to profitability in the near term.

Strong Trajectory Anticipated for NGENLA Plus Additional Milestone Payments

NGENLA's growth potential excites with anticipated growth over 12%, along with the prospect of reaping an additional $100 million from milestone payments tied to further approvals.

Substantial Grants Aid in Development of Multispecific Antibodies

With BARDA grants providing a solid financial foundation, OPKO advances its innovative multispecific antibodies, with a keen eye on facilitating rapid responses to emerging viruses.

Lucrative Merck Collaboration Could Yield Significant Milestones and Royalties

Collaboration with Merck on the Epstein-Barr virus vaccine presents significant financial potential, standing to rake in up to $872.5 million in milestones, supplemented with a lucrative range of royalties.

Initiation of Clinical Trials Imminent for Immuno-Oncology Candidates

Remarkable innovations in immuno-oncology drive OPKO towards launching clinical trials for solid tumor treatments in the first half of the year, signaling a commitment to addressing complex cancer challenges.

OPKO Diagnostics Seeks Profitability Following Revenue and Expense Reconciliation

While experiencing a decline in revenue due to decreased COVID testing, BioReference Health strategically adjusts, aiming to overturn its operating loss and march toward profitability.

Fiscal Strategy and Guidance for 2024 Reveal Potential and Prudence

OPKO carefully finesses its financial strategy, securing its cash position and aligning convertible debt. All eyes are on their Pharma segment's receipts, estimated at $40 million to $50 million from Pfizer. R&D spikes in anticipation of immuno-oncology trials, with concerted efforts to pivot Diagnostics to profitability by year's end.

Financial Guidance Provides a Roadmap for the First Quarter of 2024

OPKO projects total revenues of $180 million to $185 million balanced against substantial R&D and operational expenses. With a disciplined focus on stringent cost management and enhanced revenue streams, the company lays out its financial path for the upcoming quarter.

Earnings Call Transcript 2023-Q4

[Operator]

Good day, and welcome to the OPKO Health Fourth Quarter 2023 Financial Results Conference Call. [Operator Instructions] Please note, this event is being recorded. I would now like to turn the conference over to Yvonne Briggs. Please go ahead.

[Yvonne Briggs]

Thank you, operator. Good afternoon. This is Yvonne Briggs with LHA. Thank you all for joining today's call to discuss OPKO Health's financial results for the fourth quarter of 2023. I'd like to remind you that any statements made during this call by management other than statements of historical fact will be considered forward-looking, and as such, will be subject to risks and uncertainties that could materially affect the company's expected results. Those forward-looking statements include, without limitation, the various risks described in the company's SEC filings, including the annual report on Form 10-K for the year ended December 2023 and in subsequently filed SEC reports. This conference call contains time-sensitive information that is accurate only as of the date of the live broadcast, February 27, 2024. Except as required by law, OPKO undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call.

Before we begin, let me review the format for today's call. Dr. Phillip Frost, Chairman and Chief Executive Officer, will open the call. Dr. Elias Zerhouni, Vice Chairman and President, will then provide an overview of OPKO's Pharmaceutical business as well as BioReference Health. After that, Adam Logal, OPKO's CFO, will review the company's fourth quarter financial results, and then we'll open up the call to questions. Now I'd like to turn the call over to Dr. Frost.

[Phillip Frost, executive]

Good afternoon, and thank you for joining us today. 2023 was a year of significant achievement for OPKO, and we expect continued progress in 2024. In 2023, NGENLA, our long-acting growth hormone therapy, was approved by the FDA for sale in the U.S., the largest growth hormone market in the world. Pfizer, our global commercial partner, has now launched NGENLA in over 40 markets worldwide, and we're optimistic about Pfizer's ability to convert users to the weekly injection from the daily to further penetrate this growing $5.5 billion market.

ModeX made great strides last year, in particular, in executing its strategy to secure important collaborations to advance its multi-specific biologics platform into the clinic. These collaborations provide nondilutive funding to advance our unique pipeline to commercial realization. Specifically, last March, we announced an exclusive worldwide license and collaboration agreement with Merck to develop ModeX's nanoparticle vaccine candidate against Epstein-Barr virus. We received a sizable upfront payment and are eligible for milestone and royalty payments.

In September, ModeX was awarded a contract from the Biomedical Advanced Research and Development Authority, known as BARDA, to develop novel multi-specific antibodies against viruses that cause infectious diseases deemed to be public health threats. The BARDA contract included an initial payment to develop multi-specific antibodies to treat and prevent COVID-19, and additional funding may be available to develop multi-specific antibodies targeting other viral pathogens such as influenza. Elias will provide more detail on those programs.

Sales of RAYALDEE, our drug to treat chronic kidney disease patients with elevated [ power ] thyroid hormone and low vitamin D levels, grew 13% last year, and we're expecting further progress this year. We're gathering data, which indicate that RAYALDEE may slow chronic kidney disease progression. Some of you have been asking about my long-time enthusiasm for our once-weekly oxyntomodulin product to treat Type 2 diabetes and obesity. You'll remember that we had completed a successful Phase II trial achieving significant weight loss, lowering of serum cholesterol and triglycerides and lowered [ A1c ] levels. We delayed a Phase III trial when other products appeared, which provided greater weight loss.

Noting the great commercial success of these products, we decided to have a closer look at ours. The polyethylene glycol [ peg ] added to our base peptide to increase its half-life is large and bulky and increase the viscosity of the injection, which limited the maximum dose administered, which is related to the amount of weight loss. We have now found a substitute for [ PEG ], which makes our molecule size similar to those on the market. With guarded optimism, we're in early stages of preclinical evaluation of this product.

Switching to our international business, OPKO Iberoamerica, FinTech and EirGen are all doing well. Turning to BioReference Health. Our team has worked hard to improve our cost structure and enhance revenue. In addition to our expense reduction efforts, BioReference has been aiming to drive growth in higher value segments with new tests, larger customers and better insurance reimbursement. We are laser-focused on returning this segment to profitability in the near term. And again, Elias will provide more detail. With that overview, I'll turn over to Elias.

[Elias Zerhouni, executive]

Thank you, Phil, and good afternoon, everyone. As Phil mentioned, last year was quite eventful for both our operating segments of OPKO Health. And [ NGENLA ] launches in all major global markets, as mentioned by Phil, is progressing well, and we believe this drug is well positioned for significant growth. This next-generation long-acting therapy's administered once a week and not daily and assisted easing the burden, especially for the pediatric market, and increases medication adherence. NGENLA annual growth is anticipated to be in excess of 12%.

But as part of our partnership with Pfizer, OPKO's [ antilotoan ] additional $100 million in milestone payments associated with approvals for an adult indication for growth hormone deficiency and additional pediatric indications. These are global registration strategies underway for the adult application and other pediatric indications, which are currently in Phase III clinical trials.

Phil also mentioned our success last year in securing collaborations for ModeX Therapeutics with BARDA and Merck. Most recently, with BARDA, we secured an initial $59 million grant to fund R&D and clinical evaluation through a Phase I study of our multi-specific antibodies against known variants of SARS-CoV-2 for the treatment as well as prevention of COVID-19, which remains a particular [ truck ], especially for immunocompromised patients. Additional funding of up to $109 million based upon the achievement of certain milestones in the first phase may be available from BARDA to develop more multispecific antibodies targeting other viral pathogens such as influenza. And as part of the research program, gene-based delivery methods for the multispecific antibodies will be developed using mRNA or DNA vectors to supplement the body's natural protein production processes and hopefully provide BARDA with a platform that can be used very quickly for any emerging [ flat ].

In addition, we announced the collaboration with Merck to develop MDX-2201, which is our Epstein-Barr virus multivalent nanoparticle vaccine. We received a $50 million upfront payment for the license of this vaccine, with a potential $872.5 million in development and commercial milestones and scale royalties on global sales, ranging from single digit to double-digit percentages. This program truly leverages ModeX's nanoparticle-based vaccine platform, which enables simultaneous immunization against several major EBV proteins, in this case, 4 major EBV proteins, but the platform itself has the potential to, in fact, address multiple antigens against multiple viral diseases.

The market opportunity here is quite large, as the Epstein-Barr virus affects up to 95% of the global adult population during their lifetime. Moreover, there are over 260,000 cancer cases annually caused by EBV along with an association between multiple sclerosis and [ this ] virus. We're working with Merck on IND studies, and we expect Phase I clinical trials to start later this year.

To round out our ModeX pipeline, we have partnered with the NIH to develop an antiviral multispecific antibody focused on the treatment and prevention of HIV. We've had success with our first-generation candidate in the Phase I trial, and we are moving forward with a more potent next-generation tetraspecific antibody versus the previous tri-specific one. We believe there is an unmet need for a therapy that can provide long-acting protection and treatment for patients who require options beyond small molecule-based therapies.

And lastly, our immuno-oncology programs. Our focus on hard-to-treat solid tumors, as well as liquid tumors such as leukemias [ and methods ]. Our multispecific antibody candidates can simultaneously target several tumor [ intigens ] and enable better control of immune system activation. Our tetraspecific laser program to treat solid tumors is expected to enter the clinic the first half of this year.

Now I'd like to turn to a review of our Diagnostics segment via, BioReference Health. 2023 was a transition year for our Diagnostics division as we get closer to turning the corner to profitability. As you know, we implemented our REACH initiatives to reduce costs, improve efficiency and [indiscernible] productivity. For example, we've reduced our headcount by 8% or 252 headcount in 2023. In parallel, we're driving growth in various testing segments, including our higher-value specialty segments like oncology, wounds health and urology primarily through our proprietary 4Kscore test. The 4Kscore test volume has continued to perform, and we expect these volumes to continue as the test was included in the 2023 American Urology Association and the [ NCNN ] guidelines for early detection of prostate cancer and for follow-up after PSC screening for initial and repeat [ biopsy risk ] stratification. In addition, we expect that the recent expansion of insurance coverage will continue to [ bolster ] levels this year.

GenPath continued to launch innovative testing, including an expanded hematologic malignancy panel and introducing several new tests in the market that will sustain growth of the GenPath oncology products. Other advances have been made over the 2023 year. For example, we have signed over 300 new accounts in the fourth quarter of 2023 with over 40,000 accessions, additional accessions. And we've also signed major oncology groups like the Virginia Oncology -- Oncology Group with 90 oncology

[Audio gap]

starting in November.

So in summary, BioReference Health made great progress last year, and we expect to continue to build these achievements in 2024. We narrowed our operating loss sequentially. And through both expense reduction and revenue growth, we continue to feel confident that these efforts will further improve financial metrics and return this segment to profitability in the next few years. I will now turn the call over to Adam Logal to discuss our fourth quarter financial results. Adam?

[Adam Logal, executive]

Thank you, Elias. Starting with our Pharmaceuticals segment, revenue increased to $57.7 million for the fourth quarter of 2023 from $46 million for the comparable period of 2022. Revenue from products, including our international pharmaceutical businesses and RAYALDEE, increased by $5.1 million, reflecting from improvements in the number of prescriptions and in overall net price. Further, revenue increased as a result of gross profit share payments from Pfizer due to the global launch of NGENLA, resulting in $12.2 million of revenue during the quarter. The fourth quarter revenue includes a catch-up payment for the U.S. market related to the third quarter of $3.1 million.

As I mentioned last quarter, the U.S. launch occurred mid-August, and Pfizer was delayed in reporting our gross profit share amounts. And as a result, none were included in our third quarter results. Costs and expenses were [ $73.8 ] million for the fourth quarter of 2023 compared to $68 million for the 2022 period. Research and development expenses for the fourth quarter of '23 were $18.7 million compared to $16.6 million for the comparable period of 2022. This increase reflects activities for our ModeX development programs, partially by decreased spending on NGENLA as well as an R&D tax credit for our Irish activities. The resulting operating loss for the quarter ended December 31, 2023, was $16 million, a $6 million improvement from the operating loss of $22 million for the fourth quarter of 2022.

Amortization expenses related to intangible assets were $16.4 million and $16.5 million for the 2023 and 2022 4th quarters, respectively. Moving to our Diagnostics segment. We reported revenue for Q4 2023 of $124.2 million compared with $139.4 million for the 2022 period. This decline primarily reflects lower COVID testing of $7.1 million as well as a change to our estimated collections of $8.1 million, partially offset by increased testing volumes. Costs and expenses increased to $166.4 million for the fourth quarter of 2023 from $162.5 million for the 2022 period. Operating loss for our Diagnostics segment included a change in estimated collections as well as approximately $4.7 million of nonrecurring costs related to employee severance and retention programs associated with our efforts to return to profitability.

Depreciation and amortization expense were $8.1 million and $8.7 million for the 2023 and 2022 periods, respectively. Turning to our consolidated financial results. For the fourth quarter of 2023, we reported an operating loss of $69.1 million compared to an operating loss of $55.3 million for the 2022 quarter. Net loss for the fourth quarter of 2023 was $66.5 million or $0.09 per share, which compares with a net loss of $85.2 million or $0.11 per share for the 2022 quarter, reflecting lower noncash mark-to-market losses related to our investment in GeneDx.

I'd like to briefly comment on our balance sheet and the recently completed refinancing of our convertible debt. On December 31, we had 2 convertible debt issuances that were set to mature in early 2025. Our 4.5% notes, which were held by a number of institutions, and our 5% notes, which were primarily held by Dr. Frost, [ Dr. Shao ] and a long-term investor of OPKO. In consultation with our advisers at JPMorgan, we chose to issue new 5-year notes, reducing our coupon interest rate to 3.75% and took advantage of the strong demand from institutional investors to raise a total of $230 million. We used the proceeds to buy back the outstanding 4.5% notes and the 55 million shares of our common stock, and we added approximately $25 million in cash to our balance sheet.

Our 5% note holders exchanged their principal and accrued interest of approximately $71.1 million into notes with identical financial terms as the 3.75% note holders. This refinancing strengthened our balance sheet, reduced the number of shares outstanding and provided the company with additional cash to fund our ongoing development activities. The offering was oversubscribed and brought in an impressive group of new prominent investors to OPKO. During 2024, we anticipate receipt of additional nondilutive cash payments under our existing collaborations with Merck, BARDA and other potential transactions as the year progresses.

As we look ahead, we're providing the following financial guidance with the following assumptions. For our Pharmaceuticals segment, there are a number of factors that impact our gross profit share payments from Pfizer, including revenue from product sales of GENOTROPIN, [ Enegin ] and NGENLA. Global sales of GENOTROPIN for 2023 as reported by Pfizer were $539 million. Pfizer has not separately reported sales of NGENLA. However, we have observed consistent prescription growth globally for NGENLA as reported by IQVIA and Symphony. As such, for the full year, we estimate our gross profit share will be between $40 million and $50 million, although we anticipate that a number of scenarios may impact sales of GENOTROPIN and NGENLA globally. We assume a stable foreign exchange rate for our ex U.S. Pharmaceutical businesses, which will allow for continued and profitable growth.

R&D expenses for the first quarter of 2024 will reflect higher activities related to our ModeX programs, including CMC and efforts related to the initiation of our first immuno-oncology clinical trial. Those increased activities will be partially funded through our BARDA agreement and partially offset by lower R&D costs related to the wind down of our clinical operations for the ongoing open-label pediatric extension study for NGENLA, which we expect to substantially complete by the end of the first quarter.

For our Diagnostics segment, as Elias outlined, we are diligently working to align the business to achieve cash flow breakeven by the middle of 2024 and profitability by the end of the year. This work includes consolidating our geographic footprint and rationalizing our test offerings. As a result, we expect our client mix to improve and cost structure to appropriately support our go-forward strategy. During this transition phase, we expect consistent core testing volumes with a slight increase in the average per patient collection amount due to our revenue cycle management initiatives, partially offset by volume impact due to several weather events that occurred during the first quarter already.

Before considering any nonrecurring cost that may result from our restructuring activities, we expect our cost and expenses to decline sequentially by $7 million to approximately $159 million. As a result, we expect the following for the first quarter of 2024: total revenues between $180 million and $185 million; revenue from services between $126 million and $130 million, revenue from product sales between $36 million and $40 million; and other revenue between $14 million and $18 million, inclusive of the estimated Pfizer gross profit share payments between $9 million and $11 million. We expect first quarter costs and expenses to be between $235 million and $245 million, including R&D expense between $20 million and $29 million, dependent on the timing for certain CMC activities for our ModeX programs and depreciation and amortization expense of $26 million.

That concludes our prepared remarks. And thank you for your attention. Operator, let's open the call for questions.

[Operator]

[Operator Instructions] And our first question comes from Jeffrey Cohen of Ladenburg. Please go ahead.

[Jeffrey Cohen, analyst]

I guess, first, Adam, could you just recap your financials with regard to the -- the 4.5% and 5% instruments out there? So currently, the share count is down toward approximately 700, and then what would be appropriate cash and debt levels of what we're estimating pro forma?

[Adam Logal, executive]

Yes. So we ended the year with $95 million in cash. So if you pro forma in the additional $25 million, that would put us right at about $120 million in cash on a pro forma basis. The total convertible notes were just over $300 million, so just right at $300 million in principal. And you've got the share count right, the...

[Jeffrey Cohen, analyst]

Okay. Perfect. Got it. Could 1 of you discuss a little bit about the press release with regard to the Alibaba global platform in China and talk about perhaps some of the products that you're planning on offering and what would -- we should expect as far as the status during '24?

[Phillip Frost, executive]

The products involved are made by our Irish company and -- I'm sorry, by our Spanish company, and are primarily nutritional products for animals, for which there appears to be a large market in China, and it is just beginning. So there's not much else to say about it.

[Jeffrey Cohen, analyst]

Okay. Got it. And then lastly for us, could you provide any commentary on NGENLA and [ Jayawi ] going to weekly and what you've learned or what Pfizer's learned perhaps versus what's anticipated as far as costs and transferring to patients from 1 to the other and new patients and how that may look over the coming year?

[Adam Logal, executive]

I'll start off, Jeff. I think what we've seen in the markets that are the most mature from Pfizer where they launched initially is good, steady growth in the conversion is happening. Broadly, I think with 1 of the competitors launching a bit earlier in the U.S. market, we've seen that conversion happen, similar to what we've seen globally. We expect that to continue and accelerate as Pfizer enters the market as well as if [ Novo ] eventually enters the market with their long-acting products. So the conversions are happening, and we expect those to accelerate over the next 18 to 24 months.

[Jeffrey Cohen, analyst]

Okay. Perfect. And then lastly, on reality. It sounds like you're expecting growth, and it looks like Q4 had some strong growth. Could you identify for us where they may be coming from, either demographically or geographically or pricing-wise and what we should expect for that?

[Adam Logal, executive]

So Charlie, do you want to go?

[Charles Bishop, executive]

Yes, happy to do that. So we're seeing growth for a number of reasons with the [ Reality ] brand. First is the obvious passing of the adverse effects of the pandemic, which slowed the ability of our sales force to get into clinics and promote the brand, and it also slowed the ability of patients to get into the clinics to get prescriptions. That seems to have abated as of the beginning of Q2 of last year. In addition, our sales force is much more adept now at moving the product into areas of business that have low co-pays. This would include the Medicaid sector. This includes the low-income subsidy Medicare Part D patients. And it also includes the commercial patients who have 0 co-pay. So these are the main drivers of the growth in the business.

[Jeffrey Cohen, analyst]

Okay. Got it. It seems like it's on a [ mesh ] trajectory, post COVID currently. Okay. I think that does it for us.

[Operator]

The next question comes from Maurice Raycroft of Jefferies.

[Maurice Raycroft, analyst]

I was wondering if you can talk more about timing and next steps for NGENLA label expansions for the adult setting an additional pediatric indications?

[Elias Zerhouni, executive]

Yes, quickly. The adult indication, basically, we're in the process with Pfizer, obviously, to put our application to the FDA. And as I mentioned in my comments, we're in towards the end of Phase III for the pediatric indication. So timing-wise, probably the end of the year, beginning of next year for the adult and probably early next year for the pediatrics if everything as well.

[Maurice Raycroft, analyst]

Got it. Okay. And then for profit share with Pfizer, I just wanted to make sure I heard this correctly, that the guidance for 2024 is $40 million to $50 million. Is that right? And wondering if there are more details you can provide on the profit share currently and how that will change as NGENLA takes more market share from GENOTROPIN. And what would a peak profit share percent look like?

[Adam Logal, executive]

Sure. So Maurice, the way -- so the $40 million to $50 million, you're correct, is the full year guide based on the information we know today, right? So Pfizer doesn't separately forecast out NGENLA or -- or GENOTROPIN sales. So we're using our internal models to calculate what we anticipate the franchise revenues to be globally. And then we apply the various tables that we have to come up with our estimated calculation. So we've got some conservatism built into that with some uncertainty on the daily portion for GENOTROPIN and modest growth rates that we would expect for NGENLA. So you've got the $40 million to $50 million, right? So in the fourth quarter, if you take out the third quarter catch-up, we had about $9 million in gross profit share payments. So when you think about that modest growth that we're forecasting in the gross profit share, you can see what that math kind of looks like overall.

When we look out at peak, when you look at the growth hormone franchise as a whole, so the combination of NGENLA and GENOTROPIN, when the product is at its peak where we think the peak could be -- and I think Pfizer has stated what they think the total market potential is for NGENLA. It's a substantial revenue stream. We have estimated an effective royalty rate to be in the mid-20s on that franchise. So at peak, it's a pretty substantial cash flow, we would expect to see the growth from now until we hit that peak.

[Maurice Raycroft, analyst]

Got it. That's helpful. And maybe last question, just on oxyntomodulin. If you could talk about time lines for the new formulation and what would a clinical development path look like there? And is this something you're going to keep in-house or partner out? And does LeaderMed have any rights to this program?

[Phillip Frost, executive]

I think with respect to both of those questions, it's early. We'll get back to you as soon as we have something more definitive to talk about.

[Operator]

The next question comes from Edward Tenthoff of Piper Sandler.

[Edward Tenthoff, analyst]

Two quick questions, if I may. Firstly, just at a high level with respect to NGENLA versus [ GENOTROPIN ]. What are the differences that Pfizer is pushing in terms of marketing? Or is it really just a land grab at this point where they're going to the GENOTROPIN clients and converting them over and basically trying to get into as many other accounts as possible?

And then the second question really for Phil, high level, as BioReference in the Diagnostic business returns to breakeven, is the plan here still to keep that as part of OPKO or potentially to monetize it, how you have for some of the other Diagnostic segment/products, do you ultimately see this business being Pharma and Diagnostics going forward?

[Phillip Frost, executive]

For those of you who know me, you realize that, first and foremost, we will always do what's in the best interest of the shareholders in terms of creating value. So at a particular point in time, if 1 approach seems advisable, we'll certainly consider it seriously. I don't want to be more specific than that right now. But it's clear that we have an asset on our books that is, at the moment, losing money, although we're very optimistic about turning that around that highest inherent value as an asset. And so we're very mindful of that. Sure.

[Edward Tenthoff, analyst]

And then on the competition and sort of a little bit more on the marketing and the long-acting or weekly [ common growth ].

[Adam Logal, executive]

Yes. So obviously, Pfizer is leading the charge on the commercial efforts. So where we think that they are going to be very successful is in the near term is where they're alone in the market, right? So when you think about the Japanese market, which is a substantial market for the growth hormone space where they're by themselves currently, they've had meaningful market share penetration and continued growth. And there's a number of other countries where they buy themselves. They've done a great job marketing throughout Europe as well and forcing the conversion or suggesting the conversion there as well.

In the U.S. market, they've got access commercially to a strong number of plans. We think they're well positioned with their team to go ahead and take substantial share in the U.S. as well. As far as how they're going to go about that, I think that's a question for Pfizer to answer.

[Operator]

The next question comes from Yi Chen of H.C. Wainright & Co.

[Yi Chen, analyst]

Hello?

[Adam Logal, executive]

Hey, Yi. We can hear you now.

[Yi Chen, analyst]

Sorry about that. So regarding the storefront and Alibaba. Can you talk about the potential market size that OPKO can target? And what is the potential revenue contribution in 2024? And how is the current economic environment could affect your market prospects in [indiscernible]?

[Phillip Frost, executive]

This is a product line that is very successful and is sold by our Spanish unit. They manufacture the products, develop the products and have done so well that they're beginning to expand into France, as a matter of fact, they have every intention to continue to expand geographically. We were approached by a company that has a partnership with Alibaba. And thinking that because of the tremendous interest in pet animals now in China and because such products as we have are successful, that we might be willing to let them distribute them through Alibaba in China. And we said, why not? And that's where we are now. It's just getting launched. So it's too early to say much more about the market size for our products that is sold by Alibaba. It's a wait-and-see situation.

[Yi Chen, analyst]

So strictly animal health products, right? There are no human products offered on this stuff?

[Adam Logal, executive]

So there's a combination of human health and veterinary products that will eventually go on the platform.

[Yi Chen, analyst]

Right.

[Operator]

This concludes our question-and-answer session. I would like to turn the conference back over to Dr. Phillip Frost for any closing remarks.

[Phillip Frost, executive]

Well, we'd like to certainly thank you for participating in today's session. And we hope [indiscernible] be with us again when we report the first quarter results. Thank you.

[Operator]

The conference has now concluded. Thank you for attending today's presentation, and you may now disconnect.