Provide an overview of the primary business activities
of Ionis Pharmaceuticals Inc.

What unique competitive advantages
does Ionis Pharmaceuticals Inc hold over its rivals?

What risks and challenges
does Ionis Pharmaceuticals Inc face in the near future?

Summarize the latest earnings call
of Ionis Pharmaceuticals Inc.

Is it considered overvalued or undervalued
based on the latest financial data?

Show all valuation multiples
for Ionis Pharmaceuticals Inc.

Provide P/S
for Ionis Pharmaceuticals Inc.

Provide P/E
for Ionis Pharmaceuticals Inc.

Provide P/OCF
for Ionis Pharmaceuticals Inc.

Provide P/FCFE
for Ionis Pharmaceuticals Inc.

Provide P/B
for Ionis Pharmaceuticals Inc.

Provide EV/S
for Ionis Pharmaceuticals Inc.

Provide EV/GP
for Ionis Pharmaceuticals Inc.

Provide EV/EBITDA
for Ionis Pharmaceuticals Inc.

Provide EV/EBIT
for Ionis Pharmaceuticals Inc.

Provide EV/OCF
for Ionis Pharmaceuticals Inc.

Provide EV/FCFF
for Ionis Pharmaceuticals Inc.

Provide EV/IC
for Ionis Pharmaceuticals Inc.

Show me price targets
for Ionis Pharmaceuticals Inc made by professional analysts.

What are the Revenue projections
for Ionis Pharmaceuticals Inc?

How accurate were the past Revenue estimates
for Ionis Pharmaceuticals Inc?

What are the Net Income projections
for Ionis Pharmaceuticals Inc?

How accurate were the past Net Income estimates
for Ionis Pharmaceuticals Inc?

What are the EPS projections
for Ionis Pharmaceuticals Inc?

How accurate were the past EPS estimates
for Ionis Pharmaceuticals Inc?

What are the EBIT projections
for Ionis Pharmaceuticals Inc?

How accurate were the past EBIT estimates
for Ionis Pharmaceuticals Inc?

Compare the revenue forecasts
for Ionis Pharmaceuticals Inc with those of its competitors based on recent analyst estimates.

Compare the intrinsic valuations
of Ionis Pharmaceuticals Inc and its key competitors using the latest financial data.

Compare historical revenue growth rates
of Ionis Pharmaceuticals Inc against its competitors.

Analyze the profit margins
(gross, operating, and net) of Ionis Pharmaceuticals Inc compared to its peers.

Compare the P/E ratios
of Ionis Pharmaceuticals Inc against its peers.

Discuss the investment returns and shareholder value creation
comparing Ionis Pharmaceuticals Inc with its peers.

Analyze the financial leverage
of Ionis Pharmaceuticals Inc compared to its main competitors.

Show all profitability ratios
for Ionis Pharmaceuticals Inc.

Provide ROE
for Ionis Pharmaceuticals Inc.

Provide ROA
for Ionis Pharmaceuticals Inc.

Provide ROIC
for Ionis Pharmaceuticals Inc.

Provide ROCE
for Ionis Pharmaceuticals Inc.

Provide Gross Margin
for Ionis Pharmaceuticals Inc.

Provide Operating Margin
for Ionis Pharmaceuticals Inc.

Provide Net Margin
for Ionis Pharmaceuticals Inc.

Provide FCF Margin
for Ionis Pharmaceuticals Inc.

Show all solvency ratios
for Ionis Pharmaceuticals Inc.

Provide D/E Ratio
for Ionis Pharmaceuticals Inc.

Provide D/A Ratio
for Ionis Pharmaceuticals Inc.

Provide Interest Coverage Ratio
for Ionis Pharmaceuticals Inc.

Provide Altman Z-Score Ratio
for Ionis Pharmaceuticals Inc.

Provide Quick Ratio
for Ionis Pharmaceuticals Inc.

Provide Current Ratio
for Ionis Pharmaceuticals Inc.

Provide Cash Ratio
for Ionis Pharmaceuticals Inc.

What is the historical Revenue growth
over the last 5 years for Ionis Pharmaceuticals Inc?

What is the historical Net Income growth
over the last 5 years for Ionis Pharmaceuticals Inc?

What is the current Free Cash Flow
of Ionis Pharmaceuticals Inc?

Discuss the annual earnings per share (EPS)
trend over the past five years for Ionis Pharmaceuticals Inc.