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Earnings Call Analysis
Summary
Q2-2024
In Q2 2024, Dyadic International's revenue dipped to approximately $386,000, down from $837,000 a year prior, largely due to the conclusion of major research collaborations. Despite rising G&A expenses, the firm is pursuing significant growth in the alternative protein sector. They recently announced a strategic collaboration with ProLiant Health, including a $1.5 million payment and prospects for recurring revenue starting in 2025. Additionally, they aim to capitalize on the $26 billion animal-free dairy market. With ongoing vaccine development and collaborations, Dyadic is positioned for near-term revenue streams while nurturing avenues in human and animal health sectors.
Good evening, and welcome to the Dyadic Internation Q2 2024 Conference Call. [Operator Instructions]. As a reminder, this conference is being recorded today, August 13, 2024. I would like to now turn the conference over to Ms. Ping Rawson, Dyadic Chief Financial Officer. Please go ahead.
Thank you. Good evening, and welcome, everyone, to Dyadic International's Q2 2024 Conference Call. I hope you have had the opportunity to review Dyadic press releases announcing financial results for the quarter ended June 30, 2024. You may access our release and Form 10-Q under the Investors section of the company's website at dyadic.com.
On today's call, our President and CEO, Mark Emalfarb and our Chief Operating Officer, Joe Hazelton, will give a review of our second quarter 2024 business and corporate highlights including a brief summary of our recent research and business development efforts. I will follow with a review of our financial results in more detail. And our Chairman, [ Patrick Lucy ] will provide a commentary on the strategic direction of the business at the end of the call. We will then hold a brief question-and-answer session.
At this time, I would like to inform you that certain commentary made in this conference call consider forward-looking statements, which involve risks and uncertainties and other factors that could cause Dyadic's actual results, performance, scientific or otherwise, or achievements to be materially different from those expressed or implied by these forward-looking statements. That expressly disclaims any duty to provide updates to its forward-looking statements, whether because of new information, future events or otherwise. Participants are directed to the risk factors set forth in [indiscernible] filed with the SEC. It is now my pleasure to pass the call to our CEO, Mark Emalfarb. Mark?
Thank you, Ping. Welcome, everyone, and thank you for joining Dyadic Q2 2024 Conference Call. We are excited to discuss our business strategy centered on near-term licensing and product candidates is strategically positioned Dyadic to swiftly take advantage of current and upcoming opportunities. Over the next 24 months, we're focusing on achieving mobile revenue streams and significant milestones through the commercialization of products, technology licensing, fully funded collaborations and advancing our pipeline all aimed at enhancing shareholder value.
Our C1 technology continues to garner widespread recognition of its remarkable speed and productivity earning accolades not only across the country but around the world. His team [indiscernible] from academia and industry, such as world-renowned vaccinology pioneer, Dr. [indiscernible], government agencies like the U.S. FDA, BARDA, the NAH and Nimble, nonprofit organizations and 2 top 10 pharmaceutical collaborators are recognizing C1's groundbreaking potential. Meanwhile, our data is protein expression platform is already gaining significant momentum and most importantly, most importantly, generating revenue and the rapid evolving alternative protein and bioindustrial sectors.
We are committed to leveraging our microbial protein production platforms C1 and depos to develop recombinant proteins, enzymes, antigens and antibodies across our core sectors: alternative proteins and on human health. These efforts are expected to open up new revenue streams, driving substantial value creation for Dyadic and our partners in both the pharmaceutical and nonpharmaceutical markets. I will now turn the call over to our Chief Operating Officer, Joe Hazelton, to provide an update on our business results for the second quarter. Joe?
Thank you, Mark. In the second quarter, our business development efforts in the alternative protein sector are continuing to bear fruit, showcasing the potential of our microbial platforms. As part of our strategy to drive near-term revenue we have concentrated on identifying and producing high-value, high-volume recombinant protein products that can quickly and efficiently be commercialized. Our recently announced partnership for combat serum albumin is a prime example unlocking numerous opportunities within the approximately $6 billion serum albumin market. This single product offers diverse commercialization prospects across various segments.
For instance, pharmaceutical grade serum albumin has potential as a disease treatment plays a crucial role in vaccine development serves as a carrier protein for therapeutics and is a standard reagent in research and development. Additionally, recombinant albumin is valuable in diagnostics, cell and gene processing and cell culture media, particularly for [indiscernible] muscle cells for lab grown meat. The recent completion of certificates of analysis for a recombinant human and bovine albumin confirms the analytical equivalents to currently commercialize reset products. making them potentially viable for commercialization in R&D. We have also completed third-party of recombinant bovine albumin produced through our microbial platforms as a component of cell culture media.
Demonstrated its comparable effectiveness to animal-derived [ rolivinabumin ] in growing muscle cells for the culture [indiscernible], further validating its potential in this rapidly expanding market. To unlock the potential of our recombinant albumin products, we have executed a strategic development and commercialization partnership with Proliant Health and Biologics, a leading supplier of purified proteins of the diagnostic, nutrition and cell culture markets with a global customer base. This collaboration will initially focus on bringing recombinant human serum argument to market with the first product launch expected in the first half of 2025.
Under the terms of the agreement, Dyadic will receive a total payment of $1.5 million, and we expect to start receiving recurring revenue in 2025 and from our share of the profits generated by ProLiant from the sale of animal-free recombinant albumin products made using Dyadic filamentous fungal microbial platforms. A portion of the upfront payment will support the technology transfer and commercialization efforts following successful scale-up validation. We've already received a $500,000 payment and we anticipate a second $500,000 milestone payment in the late third or early fourth quarter following product testing and expect the final milestone payment upon scale-up validation projected for the fourth quarter of this year.
We're actively working to accelerate and broaden the scope of commercialization opportunities within the alternative protein sector, particularly for nonfood applications. Recently, we completed the development of DNA and the issuance of its certificate of analysis confirms its analytical comparability to existing commercial products. We've begun sampling this product and are aggressively seeking partners and customers in the global market for DNAs, ligases and RNA polymerases. a market that's valued at over $809 million in 2023, projected to grow at a CAGR of 10.63% from 2024 to 2030.
In addition, we've developed a recombinant transfer and strain at significantly high productivity in interest from global cell culture media, the global cell culture media market which was valued at $4.73 billion in 2023 and is expected to grow at a compound annual growth rate of 12.54% from 2024 to 2030. Transferrin is a key component of serum-free cell culture media with recombinant proteins and growers comprising the majority of the costs. Over 95% of web driven by albumin and [ transferrin]. Notably, more than 70% of the transfer and used in cell culture media today is produced recombinantly, making it particularly attractive product for Dyadic.
Our goal is to expedite the and application testing in the third quarter and to begin sampling as soon as possible. In other efforts to expand our presence in cell culture media, we've also begun sampling our partner Biftex patent-pending cost-reducing animal-free growth medium for which we'll earn a share of their net sales. outside recombinant cell culture products, we believe recombinant nonanimal dairy products offer Dyadic the potential for rapid commercialization opportunities. The global animal-free dairy products market was valued at over $26 billion in 2022 and is projected to reach more than $75 billion by 2032. Today's animal-free dairy products are produced via precision microbial fermentation technology. A market driven by evolving consumer preferences and concerns over health issues associated with traditional cow milk, such as lactose intolerance and allergies.
Despite the current high cost of animal-free dairy, this off school alliance with our expertise in producing large quantities of cost-effective recombinant proteins using our microbial expression platforms. We're making steady progress with our partnership to develop nonanimal dairy enzymes which was established less than a year ago. While we encountered a delay in earnings a success due to a longer-than-expected validation, we believe we have now met our targets for this project and expect to receive a success fee of $500,000 in the fourth quarter of this year. In the second quarter, interest in our non-animal alpha Lacta albumin product has resulted in a nonexclusive joint development agreement with a top 10 global dairy company to create a food-grade alpha-lacta albumin product. We're also in active discussions with 3 other alternative dairy protein companies interested in commercializing this product.
To further expand our nonanimal dairy pipeline, we are -- we plan to begin sampling in the competitive beta-lactoglobulin markets. We are in ongoing discussions to develop a recombinant [indiscernible] food grade product with the goal of finalizing the development and commercialization agreement in the third quarter. Over the last year, we have been actively developing several bioindustrial grade enzymes with applications across multiple industries, including nutrition, biofuels and bio refining. In a partnership with Farmbox, we have successfully developed a cellulosic enzyme for the biofuel industry undergoing testing by potential customers.
Additionally, Dyadic has created enzymes initially targeted at the pulp and paper industry with promising potential for use in the biogas and biofuel sectors as well. Our goal is to be in commercializing these products within the next 12 months which we believe will drive revenue growth in the future. While the alternative protein segment is our primary focus for near-term growth and revenue, we remain deeply committed to the long-term potential of animal and human health pharmaceutical segments. The successful completion of our first in-human Phase I study for C1 produced protein has generated significant interest from academia, government, industry and nonprofit organizations.
Since the beginning of the year, we've initiated over 14 fully funded human health vaccine and antibody projects, including 2 with top 10 pharmaceutical companies. These third-party funded programs cover a wide range of disease areas and further showcase Dyadic ability to produce both standard and complex molecules. Our C1 platform has successfully expressed multiple potential infectious disease vaccine antigens, including those for HPV, HIV, several RSV antigens and Plasmodium parasitic diseases. Additionally, in the second quarter, Dyadic delivered 3 successfully expressed monoclonal antibodies, or MABs, for evaluation as neutralizing agents for infectious disease with 2 more mAbs in development, 1 of which is for our top 10 pharmaceutical company.
As the H5 bird flu continues to spread globally, affecting wild birds, poultry and even U.S. dairy cows, there has been a growing interest from human and animal pharmaceutical companies, especially with the recent human cases reported among U.S. dairy and poultry workers. In response, Dyadic commissioned an independent vaccine expert to assess its [ adjuvanted ] H5 Cloud 2.3.3.4.B, a [indiscernible] avian influenza or Birdflu, ferritin nanoparticle human vaccine candidate, developed in collaboration with Virovax LLC. The expert assessment provided a positive outlook on the initial animal studies highlighting both the strength of the C1 vaccine manufacturing platform and the H5 avian influenza or bird flu [ Vertonnanoparticle ] vaccine candidate's potential to generate strong neutralizing antibodies for use in humans as well as possibly in poultry, cattle and other animals.
Earlier in the second quarter, Dyadic and Virovax announced preclinical animal testing for our H5 AB an influenza or bird flu Ferte nanoparticle vaccine candidate which demonstrated a robust immune response in rabbits. The potential H5 bird flu recombinant protein human vaccine candidate combines static C1 single-step fartinanoparticle antigen production with Veravax' novel antigen and adjuvant. This promising candidate has been presented to several government agencies, including [indiscernible], NIH and the White House Office of Pandemic Preparedness and Response policy. Two additional U.S. government patients are currently scheduled for next week.
Furthermore, the initial preclinical animal studies indicate that the C1 produced H5 avian influenza or bird flu, [ veritonanoparticle ] vaccine candidate generates high levels of neutralizing antibodies against the 3 primary circulating bird flu viruses. This has increased the potential interest in the animal health sector particularly for use as a vaccine in poultry and cattle to combat the ongoing avian influenza outbreak. We're actively providing samples of the reduced bird flu recombinant far to nanoparticle vaccine antigen to various human in animal pharmaceutical companies for further evaluation.
Alongside the continued progress and expansion of our partnership with Fiber Animal Health, we're capitalizing on the heightened awareness brought by the bird flu outbreak in the Animal Health segment by intensifying our business development efforts in animal health, initially focusing on recombinant protein vaccines for a pandemic response and preparedness. We remain laser-focused on evaluating product opportunities with financial rigor, ensuring we fully capture the value of Dyadic technology and expertise. We're committed to driving near-term revenue growth in the alternative protein segment while simultaneously building mid- to long-term value in animal and human health markets. With that, I'll turn the call over to our CFO, Ping Rawson, to cover our [indiscernible]. Ping?
Thank you, Joe. Thank you, everyone, for joining our call today. I will now go over our key financial results for the quarter ended June 30, 2024, in more detail. You can find additional information in our earnings press release and Form 10-Q, which we filed earlier today. Revenue for the quarter ended June 30, 2024, decreased to approximately $386,000 compared to $837,000 for the same period a year ago. The decrease in revenue was due to the winding down of several large research collaborations conducted in 2023. Cost of research and development revenue for the quarter ended June 30, 2024, decreased to approximately $302,000 and compared to $793,000 for the same period a year ago. The decrease followed the winding down of several large research collaborations. Research and development expenses for the quarter ended June 30, 2024, decreased to approximately $516,000 on compared to $918,000 for the same period a year ago.
The decrease primarily reflected the wind down of activities related to the company's Phase I clinical trial of DYN-100 and several internal research projects. G&A expenses for the second quarter of 2024 increased to approximately $1.68 billion compared to $1.43 million for the same period a year ago. The increase was due to increases in share-based compensation expenses of $84,000, legal expenses of $81,000 in business development and investor relations expenses of $60,000 and other increases, partially offset by decreases in management incentives of $36,000 and insurance expenses.
Loss from operations for the quarter ended June 30, 2024, decreased to $2,043,000 compared to $2.29 billion for the same period a year ago. Net loss for the quarter ended June 30, 2024, was approximately $2.45 million or $0.07 per share compared to a net loss of $2,153,000 or $0.07 per share for the same period a year ago. On March 8, 2024, the company issued an aggregate principal amount of $6 million of 8% senior tier convertible promissory notes due March 8, 2027 in the private placement. The convertible notes have a conversion price of $0.09 with no warrants. During the second quarter, of the notes were converted into the company's common shares.
As of June 30, 2024, we have cash and investment-grade securities, including accrued interest of $10.1 million compared to $7.3 million as of December 31, 2023. In July, the company received an initial payment of pursuant to our license and development agreement with ProLiant. We expect our cash burn for the second half of 2024 will be approximately $3 million. I will now turn the call over to tide Chairman, Patrick Lucy, for closing remarks.
Thank you, Ping. First, I would like to thank you all for joining the call today and your continued support of Dyadic Several months ago, we redefined the Dyadic corporate strategy to focus on opportunities to deploy the Dyadic C1 and databus platform protein production technologies to generate significant near-term revenue and near-term recurring revenue while also advancing our efforts in mid- to long-term value creation. This strategy is focused on 3 distinct market sectors, including alternative proteins, animal health and human health.
In today's call, you've heard that strategy playing out with executed agreements and significant activity in each of the sectors with a particular emphasis on the alternative protein sector. The transaction with ProLiant is a great example of that focus. We believe the ABN influenza vaccine candidate presents Dyadic with a significant opportunity we are currently seeking pathways to advance the candidate through nondilutive approaches. We will continue to update investors on progress in the coming months. I'm extremely pleased with our management team and our Board for their focus and commitment to our company's strategy and look forward to announcing additional transactions in the future.
With that, I will ask the operator to begin our Q&A session. Our CEO, Mark Emalfarb, and our management team will respond to your questions. Each caller will be allowed one question and one follow-up question to provide all callers an opportunity to participate. If time permits, the operator will allow additional questions from those of you -- from those who have already spoken. Operator?
[Operator Instructions]. The first question comes from John Vandermosten with Zacks.
Congratulations on the new Alpha lactalbumin deal. I had a couple of questions on that. I guess, first of all, what's the size of that market? And who are the customers for the product?
Jo, do you want to answer that?
Sure. And John, thanks for the question. The market -- the [indiscernible] is approximately a $700 million market. Now that includes milk derived products. The recombinant segment is smaller. I don't have a great number for that for you, but I would say it's probably in that $30 million to $40 million range currently -- it's obviously expanding as people are looking into producing this recombinantly similar to what they've done for HMOs and other products in this space. So with that being said, that's the central market potential, the customer, everything from the large dairy companies like the [indiscernible], Nestle to just about -- well, and also a lot of the newer companies in precision fermentation. So we have, obviously, multiple opportunities, but it's essentially the food-grade dairy companies that we're looking at.
Okay. And I guess that would be Dapibus, right? This is the Dapibus [indiscernible].
Yes. You're correct.
Okay. And then just another question on that theme. Is there a clear pathway here to revenue revenues outlined in the with the dairy company kind of as you have with the albumin deal with Proliant
Yes. The base, obviously, on the performance of the strain and hitting certain commercial targets, there are milestones and royalty payments associated with the development.
Okay.
Joe, I think maybe you can expand on the transfer opportunity as well because I think that's a huge opportunity for us. And I think explaining that a little bit would be helpful.
Sure, Mark. The [indiscernible] opportunity is similar to that of alpha-lactalbumin in that it's a very high-growth market for recombinant products, given that it's a very high price point. So the average cost of a kilogram of transferring is roughly $400,000 to $500,000. So obviously, animal-derived. Recombinant production is increasing, but it's a tricky component to produce. So being able to produce it at the titers that we are today, we believe that we can significantly reduce that cost.
And as I mentioned in the question of the call, the majority of cell culture media costs, and that's the media that you grow not just animal muscle cells, but it's also used to grow, show cells for production of other monoclonal antibodies and other pharmaceutical agents with any cell culture media component can grow basically a million cells. So it has multiple uses and multiple offtakes across the segments. The difference is, is that albumin and transferrin make up 95% of the cost of cell culture media. So if you look at, let's just say, a leader of media that you'd use to grow either animal muscle cells for lab-grown meats or you'd use it to grow show cells for making a monoclonal.
95% of those costs are from albumin and transfer and the remainder is from growth factors and some other high-value targets in there as well, which were we're looking at. But that's the particular opportunity with transfer. And given in that space, utilization today is already recombinant and it's looking to increase because, again, it's one of those markets where it's an extremely expensive product to drive naturally because there's not a lot of it in basically 1 million blood. It's much easier to produce recombinantly and potentially more regulatorily acceptable as well. So I do believe that's a significant opportunity that's already generating interest. And obviously, we have continued development we need to do.
[Operator Instructions].
Pat, is there anything you want to add we're waiting to see if anyone else is going in?
No, I think I've covered it in the remarks.
We do have a follow-up from John Vandermosten with Zacks.
Kind of a bigger picture question. for you on C1. As we look at kind of how the expression system has evolved over time, how has it changed over the last 5 years?
That's a good question. It's changed from I guess, from darkness to light or night a day. And what I mean by that is, when we transitioned the C1 cell line from the industrial sector into biopharmaceuticals, there was a lot of work we had to do to make it so that it not only produce a lot of something, but producing in a stable form. And as you know, we've knocked out a total now of 14 or 15 different genes with proteases in addition to other background proteins so that we can produce high levels of low-cost proteins that are stable.
And then most importantly, although we had certain animal data prior to doing all of that, we've expanded the animal data from rats to lands to chickens to all kinds of other thing hamsters. But most importantly, with the DYAI-100 Sars-CoV-2 RBD Booster, Phase I trial, we've now demonstrated for the first time ever a protein produced from our C1 cell line and for that matter, [indiscernible] fungal cells can be used safely and induce an immune response. And we did that both at the whole dose, and we got good neutralizing antibodies and cellular immunity.
So that has opened up the doors very wide and it seems to be growing even wider as we develop more and more antigens for the vaccine. So from a recombinant protein vaccine platform, we believe that we have the most efficient faster the largest quantity lowest cost antigens for vaccines that can be released sooner. Because in the end, we don't have viruses to remove like T cells and viral clearance or the back of virus cells. So it's not only faster, quicker and cheaper, but at least it's sooner. We believe we're going to transform our combinant protein production of antigens for human and animal health.
So hopefully, that gives you an idea of the tremendous progress we have made -- and now the validation, as we've talked about, from academia, industry, government, nonprofits, you name it and virtually on every continent on this planet. We're starting to get recognition. We're getting more and more credibility. The technology is getting more broadly applicable. And as Joe pointed out, we've produced things like HPV, which as you know, is a massive market opportunity and sales today in the billions and billions of dollars. We've also produced multiple versions of an RSV antigen and a variety of others well.
Do you have time for one more from me? I don't want to use up all my questions.
Yes. No, we're happy to answer the questions and provide information that's helpful.
Yes. So just one other thing on ProLiant, and Joe and I had a chance to talk about this before, but I don't know if I asked this question about just the relative margin on the C1 produced product versus what the -- what Proliant already doing right now with the animal-based albumin. Do you get a sense of what the relative attractiveness is of the comment C1 versus their product right now in terms of margins?
Well, important to answer that, just to clarify, they're making bovine [indiscernible] right now. So this is [indiscernible] on the human side. But Joe, you can go forward.
No. Actually, that's exactly what I was going to say. It's an expanding customer market for them because they don't have a -- well, they don't have very combinant product today. and they don't have humans road, they only work in the bovine protein space. at the current time. So this is a nice expansion. The use case, though, for human seriatum and [indiscernible] been in certain instances, is the same for things like cell culture or medical device coding. Those are things that you could potentially use other product depending on what the need of the application is there'd be certain reasons why you'd want to use human versus bovine and vice versa, a lot of it is driven by cost.
But as far as the margin attainment, I really don't want to speak for them, but obviously, we want to look to be able to provide a cost-effective product to the market in terms of a recombinant human thermal and for any application. And obviously, there's room for improvement in the price in that space. But I don't want to predict obviously what the potential margins for them could potentially be or what they're shooting at the current time.
And just to add, John, to that, keep in mind, with the strength of our upstream processing, Reliant also brings in the strength of downstream processing in terms of scale in and cost. And of course, they have access to the market because they've been selling in this market for years. So we have immediate market access we do.
[Operator Instructions]. There are no further questions in queue at this time. I would like to turn the call back over to Dyadic CEO, Mr. Mark Emalfarb. Please proceed.
Thank you. Pat and Joe have indicated, Dyadic is fully committed to driving near-term revenue and growth by pushing the boundaries of innovation and accelerating commercialization. We are expanding the use of our C1 and databus microbial protein production platforms across our 3 core sectors: alternative proteins and animal and human health. This is an incredibly exciting time in Dyadic history, and I believe we are uniquely positioned to wily capitalize on both current and emerging opportunities. I want to thank you for joining us today's second quarter 2024 Conference Call. We look forward to updating you on our continued commercial and scientific progress during our next call. Stay tuned for more exciting developments from Dyadic.
The conference has now concluded. Thank you for attending today's presentation. You may now disconnect your lines at this time.