Cytek Biosciences Inc

NASDAQ:CTKB

Earnings Call Analysis

Revenue Growth Exceeds Expectations

The company closed the fiscal year with noteworthy performance, recording a total revenue of $193.4 million, signifying an 18% increase over the previous year and exceeding the set guidance. This growth includes a significant contribution from the acquisition of Luminex's product lines, which added $28.7 million to the revenue despite only accounting for ten months of sales due to the timing of the acquisition.

Organic and Acquired Instrument Demand

Demand for the company's organic instruments remained robust, with the Cytek Aurora and Northern Life instruments leading sales. A total of 478 organic Cytek instruments were sold worldwide, while the Luminex acquisition led to 219 sales of Amnis and Guava instruments. This expansion of the product portfolio has been beneficial, but it was acknowledged that the overall challenges of 2023 required proactive strategies to maintain profitability.

Global Footprint and Revenue Streams

The company's instruments are now present in over 70 countries, with the majority of revenue derived from the USA (53%), followed by EMEA (28%), and Asia Pacific (19%). The Amnis and Guava products showed particularly strong performance in EMEA. Diversification of revenue streams, including relations and service businesses, is expected to be a driver of future growth for the company.

Strategic Acquisitions and New Launches

The successful integration of Luminex's flow cytometry and imaging business is a critical strategic milestone, already yielding benefits like service revenue growth and margin improvements. The fourth quarter also saw the launch of the Cytek Orion smart cocktail reagent mixer and surpassing expectations with Cytek Cloud's adoption, further cementing the company's commitment to innovation and excellence.

Regulatory Achievements

Ahead of regulatory requirements, the company secured IVDR compliance in the EU and bolstered its certification in California, demonstrating its dedication to meeting stringent quality standards and serving clinical markets responsibly.

Partnership for Innovation

A partnership with the Center for Genomic Regulation and Pompeu Fabra University signifies the company's intent to drive technological innovation for the scientific community, heralding the development of new tools and applications in collaboration with notable research institutions.

Focus on 2024 Strategic Priorities

The company's main strategic focus for 2024 is to bolster its competitive position through financial discipline, operational excellence, revenue growth, margin expansion, and capital efficiency, aiming to maximize free cash flow and sustainable profitability.

Fourth Quarter Financial Highlights of 2023

The fourth quarter of 2023 ended on a high note with $58.6 million in revenue (a 21% increase from prior year), gross profit of $33.7 million, net income of $6.3 million, and a solid cash reserve of $262.7 million. Although there has been an increase in operating expenses, primarily due to the Luminex acquisition, the company succeeded in maintaining profitability and a positive net income.

Revenue Outlook and Profit Commitment for 2024

The company projects a modest 5% to 10% growth in revenue for 2024, forecasted to be between $203 million to $213 million. Additionally, there is a reasserted promise for profitability, with an anticipation of positive net income and operational business profitability as measured by adjusted EBITDA for the year.

Earnings Call Transcript 2023-Q4

[Operator]

Good day, and thank you for standing by. Welcome to the Cytek Biosciences Fourth Quarter and Full Year 2023 Earnings Conference Call. At this time, all participants are in a listen-only mode. After the speakers' presentation, there will be a question-and-answer session. [Operator instructions]. Please be advised that today's conference is being recorded. I would now like to hand the conference over to your first speaker today, Paul Goodson, Head of Investor Relations. Please go ahead.

[Paul Goodson, executive]

Thank you, operator. Earlier today, Cytek Biosciences released financial preliminary results for the quarter and year ended December 31, 2023. If you haven't received this news release or if you'd like to be added to the company's distribution list, please send an e-mail to [e-mail]. Joining me today from Cytek are Wenbin Jiang, CEO; and Patrick Jeanmonod, Chief Financial Officer. Before we begin, I'd like to remind you that management will make statements during the call that are forward-looking statements within the meaning of the federal securities laws, including statements regarding Cytek's business plans, strategies, opportunities and financial projections. These statements are based on the company's current expectations and inherently involve significant risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled Forward-Looking Statements in the press release Cytek issued today and in Cytek's filings with the SEC. This call will also include a discussion of certain financial measures that are not calculated in accordance with generally accepted accounting principles. Reconciliations to the most directly comparable GAAP financial measure may be found in today's earnings release submitted to the SEC. Except as required by law, Cytek disclaims any duty to update any forward-looking statements, whether because of new information, future events or changes in its expectations. This conference call contains time-sensitive information and is accurate only as of the live broadcast, February 28, 2024. Finally, I would like to mention that Cytek will be participating in a variety of industry and academic conferences throughout 2024. While these are primarily geared to the scientific community, they may offer an opportunity to interact with users of our technologies to learn why Cytek's instruments are so highly valued by our customers. There is a cost to attend most events, and we have a limited number of spaces to accommodate members of the financial community. So if you are interested in attending, please contact me. With that, I will turn the call over to Wenbin.

[Wenbin Jiang, executive]

Thanks, Paul. Welcome, everyone, and thank you for your interest in Cytek. On the call today, I will discuss our results for the fourth quarter and the full year of 2023, briefly highlight our achievements in 2023 and provide some details on our strategic objectives for the year. Then I will turn the call over to Patrick for a deeper look at our financials and our outlook for 2024 before we open it up for Q&A. We delivered solid total revenue growth in the fourth quarter, which brought our total revenue for 2023 to exceed our guidance range. Specifically, in the fourth quarter, we grew revenue to $58.6 million, an increase of 21% over the prior year. Total revenue for 2023 was $193.4 million, representing an increase of 18% over 2022. This included approximately $9.8 million and $28.7 million of revenue from the product lines acquired from Luminex during the last 3 and 12 months ended December 31, 2023, which included only 10 months of revenue contribution from the Amnis and Guava product line. Notably, we continue to see steady demand for our organic instruments in 2023, the majority of which were our Cytek Aurora and Northern Life instruments. We also saw increased demand for Aurora sales orders. While our fourth quarter performance is encouraging, 2023 overall were challenging with dynamic macroeconomic market conditions impacting our business and growth across our sectors. We took proactive steps to address these temporary headwinds and execute a balanced business strategy to drive continued growth and deliver profitability. As part of this initiative, we implemented actions to align our cost structure to remain an agile organization. Following the completion of our integration of the Amnis and Guava product launch from Luminex. Earlier this quarter, we streamlined our organization to eliminate redundancies, arising out of the acquisition and focus on areas where we see the greatest potential for long-term value creation. While it is very hard to pass away, we valued members of our team, the rightsizing of our organization will enable us to increase our operational efficiency as we execute our growth strategy and support our commitment to remaining a profitable company. During 2023, we expanded our global footprint with 478 organic Cytek and 219 Amnis and Guava instruments sold. These 478 organic instruments bring the all-time total of organic instruments placed to 2,148. Our instruments are used today in over 70 countries and regions. For the year ended December 31, 2023, our revenue distribution reflects a balance of 53% attributed to the USA, 28% to EMEA and 19% to Asia Pacific and others. Due to the sales performance of the acquired Amnis and Guava products, our EMEA numbers were strong in the fourth quarter and the full year 2023. We have more than 1,500 broad-based customers across multiple verticals and the revenue categories represented at the end of 2023 by approximately 43% academic and government-owned institutions and the 57% pharma, biotech distributors and CRO. We delivered growth across our diversified revenue streams, including with our relation portfolio and with our service business. It is that we expect to be leading growth drivers for Cytek in the future. This ongoing positive trend reflects the utilization of our instruments and the synergetic effect of our key revenue drivers, instruments, relations and services. 2023 was a transitional year for Cytek. We strategically expanded our portfolio and strengthened our near- and long-term competitive foundation in flow cytometry. We acquired Luminex flow cytometry and imaging business about ego and successfully completed the integration by year-end, including cross-training both service teams. This significant milestone enables efficiencies across our organization with, first, access to new cell imaging and capital fluidics technology. Second, a large global presence with access to new markets and research areas; and third, improve the go-to-market and operational effectiveness with a larger installed base and a deep bench of flow cytometry experts, providing synergies in our service operations. With the integration complete, we have already realized some significant benefits from the transaction. These benefits include a meaningful growth in our service revenue and gross margin. Improvement in Guava's gross margins and a strong performance in the EU enabled by Amis and guava. We are also pleased to see some early successes with the convergence of Guava users to Northern Life as well as some high-margin sales through the bundling of Amnis image stream with Aurora and our shareholders. Overall, we are excited to continue to value the Amnis and Guava acquisition as an important success for our company. In the fourth quarter, we also launched the Cytek Orion smart cocktail reagent mixer that simplifies and accelerates the workflow and reduces reagent waste. Notably, the Cytek Orion system is unique in that it is focused solely on cocktail making for sample preparation, enabling a smaller footprint and making it ideal for applications such as drug discovery that will use the same culture multiple times. It also ensures that users are only paying for features that they need at a lower price point than competitive solutions. The introduction of this unique new preparation device moves the side roadmap forward, expand our suite of solutions for the cell analysis market and strengthens our offerings for pharma, biotech and CRO customers to drive utilization of our solutions and to accelerate new adoption, we delivered software enhancements and functionalities to Cytek Cloud in 2023, supporting our growing customer base with an integrated end-to-end operating system for our cell analysis platform. Customer adoption of Cytek Cloud has surpassed expectations. We now have over 6,000 users and an average of 3 Cytek Cloud users per installed Cytek FSP instrument. On the clinical front, in 2023, we continued to stay ahead of the regulatory curve by securing IVDR compliance in the EU and the continued growth in clinical applications in China. Relevant to our worldwide operations, we also received our ISO 13485 quality management system certification of our headquarters and manufacturing operations in Fremont, California to produce our flow cytometers, reagents and accessories. This certification bolsters our plans to focus on the translational and the clinical market and sends a strong signal to customers in these segments that we are committed to serving them, taking every step necessary to responsibly do so in the future. Recently, we were excited to announce that we signed an agreement with the Center for Genomic Regulation and the Pompeu Fabra University, CRG, UPF in spend to drive technological innovation and accelerate discoveries for the scientific community. The CRG, UPF flow cytometry unit is used by more than 500 researchers for more than 100 research projects every year. Under the terms of the agreement, Cytek will provide its [Indiscernible] cytometry platforms along with trend support personnel to the CRG,UPF flow cytometry unit headquarters. Together, with the integration of the institutes and the core facilities, we will work to explore new applications and develop new tools and solutions to address the challenge faced by the scientific community. In summary, I'm proud of our team's achievements in 2023 amidst challenging market conditions. Importantly, I remain confident in our long-term growth trajectory and the value creation across our business despite near-term headwinds that we cannot control. Our strategic priorities in 2024 are centered on fortifying our competitive position with a keen focus on financial discipline and operational excellence and efficiency. Our team is laser focused on 3 key items to drive our business, revenue growth, margin expansion and capital efficiency to deliver sustainable profitability and maximize free cash flow. With this various focus on driving profitable growth, we are making prudent investments in the group to position ourselves as a leader in flow cytometry. Cytek remains on the forefront of innovation and industry leadership, and we are excited for our bright future ahead. With that, I will now turn the call over to Patrick for more details around our financials.

[Patrik Jeanmonod, executive]

Thanks, Wenbin. Total revenue for the fourth quarter of 2023 was $58.6 million, a 21% increase over the fourth quarter of 2022. This included approximately $9.8 million of revenue from the product and services acquired from the Luminex transaction, which closed on February 28, 2023. Organic revenue, which excludes revenue from the acquired products and services was $48.8 million, an increase of 1% compared to the fourth quarter of 2022. For the quarters following the 1 year anniversary of our Luminex acquisition we will no longer provide the breakout of this inorganic revenue. Therefore, while we will report organic and inorganic revenue for our first quarter of 2024, we will see providing the breakout for the second and future quarters. Gross profit was $33.7 million for the fourth quarter of 2023, an increase of 15% compared to a gross profit of $29.4 million in the fourth quarter of 2022. Gross profit margin was 57% in the fourth quarter of 2023 compared to 61% in the fourth quarter of 2022. Adjusted gross profit margin in the fourth quarter of 2023 was 60% compared to 62% in the fourth quarter of 2022, after adjusting for stock-based compensation expense and amortization of acquisition-related intangibles. Operating expenses were $32.8 million for the fourth quarter of 2023, a 12% increase from $29.3 million in the fourth quarter of 2022. The increase in operating expenses was primarily due to expenses related to the Luminex transaction and personnel-related expenses across sales and marketing and research and development. Research and development expenses were $10.9 million for the fourth quarter of 2023 as compared to $9.7 million for the prior year period. Sales and marketing expenses were $11.6 million for the fourth quarter of 2023 as compared to $9 million for the prior year period. General and administrative expenses were $10.3 million for the fourth quarter of 2023 as compared to $10.5 million in the prior year period. Income from operations was $0.9 million for the fourth quarter compared to an income from operations of $0.1 million for the fourth quarter of 2022. The net income in the fourth quarter of 2023 was $6.3 million compared to net income of $3.7 million in the fourth quarter of 2022. Additionally, adjusted EBITDA in the fourth quarter of 2023 was positive $11 million compared to positive $6.6 million in the fourth quarter of 2022 after adjusting for stock-based compensation expense. Now for the full year 2023. Total revenue for the year ended December 31, 2023, was $193.4 million, an 18% increase over the year ended December 31, 2022. This included approximately $28.7 million of revenue from the product and services acquired from the Luminex transaction, which closed on February 28, 2023. On a constant currency basis, total revenue was $194.1 million, an increase of 13% over the full year of 2022. The total revenue in 2023 was driven by revenue contribution from the products acquired from the Luminex transaction, along with continued sales of the Cytek flow spectrum instruments. Gross profit was $110.1 million for the year ended December 31, 2023, an increase of 9% compared to a gross profit of $101 million in the year ended December 31, 2022. Gross profit margin was 57% in the year ended December 31, 2023, compared to 62% in the year ended December 31, 2022. Adjusted gross profit margin in the year ended December 31, 2023, was 59% compared to 62% in the year ended December 31, 2022, after adjusting for stock-based compensation expense and amortization of acquisition-related intangibles. The lower product gross margin were driven primarily by higher material costs, acquisition costs and by less favorable instrument product mix following the Luminex transaction. Operating expenses were $136.8 million for the year ended December 31, 2023, a 33% increase from $102.8 million in the year ended December 31, 2022. The increase was primarily due to the increased headcount and personnel-related expenses across R&D and sales and marketing. Research and development expenses were $44.2 million for the year ended December 31, 2023, compared to $34.9 million for the year ended December 31, 2022. Sales and marketing expenses were $49.1 million for the year ended December 31, 2023, compared to $33.2 million for the year ended December 31, 2022. General and administrative expenses were $43.5 million for the year ended December 31, 2023, an increase from $34.7 million for the year ended December 31, 2022. Net loss in the year ended December 31, 2023, was $11.3 million compared to net income of $2.5 million in the year ended December 31, 2022. Adjusted EBITDA in the year ended December 31, 2023, was $13.7 million compared to $21.2 million in the year ended December 31, 2022, after adjusting for stock-based compensation expense and other nonrecurring expenses, we are committed to improving these metrics going forward. Cash, cash equivalents, restricted cash and short-term investments were $262.7 million as of December 31, 2023. This represents a decline of $81.3 million from the $344 million at the end of December 2022, primarily due to the Luminex transaction, our stock repurchase program, partially offset with cash generated by the business. Our strong balance sheet, free from external operational and financial needs underscores our organization's vitality. With healthy cash reserves and profitability track record we continue to operate from a position of strength that enables our global growth efforts. During the fourth quarter we continued to repurchase our stock, following the $50 million repurchase authorization we announced in May last year. We repurchased approximately $34.7 million worth of site stock in open market transactions in the fourth quarter. Share repurchase under this program are canceled, leaving us with approximately 130.7 million shares outstanding as of December 31, 2023. Approximately $44.2 million of the original $50 million repurchase authorization was completed. Although that authorization expired at the end of 2023, we are evaluating whether to extend it and if so, by how much. Now turning to our revenue outlook for 2024. We have been encouraged to see modest improvement in customer spending pattern in the fourth quarter, and we are seeing some follow-through that strength in the first quarter of 2024. For the full year 2024, we expect modest growth across all our product lines with the build of the growth being weighted towards the back half of the year, consistent with historical spending patterns in our customer base. Taking these factors into account, we are anticipating our 2024 revenue to be in the range of $203 million to $213 million, representing 5% to 10% growth over 2023 total revenue, assuming no change in currency exchange rates. Today, we are reiterating our longstanding commitment to operating the business profitably on an annual basis as measured by adjusted EBITDA. In addition, for the full year 2024, we expect to report positive net income. As Wenbin mentioned, we continue to focus on improving operational efficiencies across our business and aligning our overall cost structure to ensure that we remain an agile organization in the best possible position to drive growth and deliver profitability. Within these goals, we are committed to investing in the Cytek brand through a variety of efforts and innovation through our strong commitment to new product development. As a possible addition to this initiative, Cytek is continuing to evaluate opportunities to accelerate our revenue growth through M&A and/or other corporate development actions, which will be subject to stringent financial operational, technical, digital and market presence carriers. With that, I will turn it back over to Wenbin.

[Wenbin Jiang, executive]

Thanks, Patrick. I'm very proud of our Cytek team around the world for successfully navigating through a tough environment to meet the needs of our customers. It is their shared the belief in our mission, combined with strong execution of our strategy that position Cytek as an industry leader in advancing the next generation of cell analysis. This year, we will continue to deepen our customer relationships to drive greater adoption and the utilization of Cytek cell analysis solutions and innovation that supports their priorities to push the bounds of scientific discovery and clinical progress. I want to thank everyone for joining the call today, and we will now open it up for questions. Operator?

[Operator]

Thank you. At this time, we will conduct the question-and-answer session. As a reminder, [Operator instructions]. Please standby while we compile the Q&A roster. Our first question comes from Matt Sykes with Goldman Sachs.

[Unknown Analyst]

This is Ivy on for Matt. What are you seeing in the academic market, both in 4Q? And then what are your expectations for 2024? Maybe just talk through what your customers are saying in that market and how your sales funnel looks going into the year.

[Patrik Jeanmonod, executive]

So looking at the -- Ivy, it's Patrick, I hope you can hear me okay. So we continue to see strength in the academia, but we've actually seen higher strength in the biotech segment.

[Unknown Analyst]

Okay. Great. And then I think you said for 2024, you're expecting sort of a broad range of improvement across the different instrument types, but maybe talk through different trends you're seeing within each category? And maybe talk about the higher-end instruments and how those are trending?

[Patrik Jeanmonod, executive]

Yes. I can give a first crack, and maybe Wenbin can augment. So obviously, one instrument that has created a lot of demand is the cell sorter. So we expect the cell sorter to continue to grow nicely in this year. We also expect to see continued growth on the 2 high-end products that we have, which is the Aurora and the Amnis family products, along with the normalize. So overall, we expect product to continue to grow this year with pediments in the second half of 2024.

[Operator]

Our next question comes from David Westenberg with Piper Sandler.

[David Westenberg, analyst]

So I know you're not breaking out Luminex revenue specifically, but just for modeling and cadence purposes, I know the Luminex acquisition, I think, closed in like middle of Q1. So how should we think about the revenue growth rate in Q1 or the cadence of Q1 relative to the rest of the year, just given the fact that we have that inorganic component? And I have a couple more follow-ups after that.

[Patrik Jeanmonod, executive]

Yes, David, thanks. It's a good question. So we expect actually the revenue in Q1 to be slightly above the overall annual growth rate for the year just because of what you just highlighted. Yes, you're correct.

[David Westenberg, analyst]

Okay. Okay. I mean small -- just small magnitude then in Q1?

[Patrik Jeanmonod, executive]

Yes. But it will be yes, correct.

[David Westenberg, analyst]

Okay. Small but noticeable. Okay. And then just on market growth of flow cytometry, I mean, -- I mean, you were a big 30% grower and kind of not to hope on the reduction and kind of where your growth rate is, but can you maybe talk about the market growth rate of flow cytometry total? I mean it's been a pretty mature technology overall so I mean, I'm guessing you were growing significantly faster than the market for a number of years. Is this 5%, 10% kind of like the way we should think about flow cytometry just as a market hole and kind of maybe that's a steady state. And then if you could break that out versus instrument consumables, I know how much faster each one grows, and I don't know if that's possible.

[Patrik Jeanmonod, executive]

So I'll give you the first crack here. So the industry, I mean, it's going in a 6% to 8% flow cytometry growth rate. Now last year this wasn't visible. I think last year was a kind of a more difficult year for the industry, yet we're coming out from an organic point of view, fairly flat with the Luminex acquisition we actually up 21% in Q4 and 18% for the full year. The expectation is that the -- on the go forward, we should see probably similar growth rates, kind of 6% to 8% for the industry, probably more skewed towards the second half. That's for the instrument and on the reagent consumable, the expectation that it should grow a little faster.

[David Westenberg, analyst]

Got it. And then -- oh, sorry.

[Wenbin Jiang, executive]

Just to add on top of that, based on the numbers we have seen through Q3 last year, cell analysis, Luminex acquisition, flow cytometry is part of the cell analysis, so was [Indiscernible] market overall. So under this environment, we still maintain the growth.

[David Westenberg, analyst]

Got it. No. And I get that there probably was a pretty challenging capital equipment environment just given the fact where budgets are at right now. So I was just curious on -- because margins were a little bit down. So I'm curious if you're seeing kind of industry discounting just given capital equipment environment or/and also if -- I think last quarter, you discussed the possibility that you might have been -- you could be doing kind of some reagent rental models or working with financing companies. Can you talk about any of those kind of dynamics as we get into -- or as we're dealing with this capital funding environment? And just as one last follow-up to that. Are you getting an indication that maybe things are getting better? I mean, there are few biotech IPOs at the beginning of the year. I don't know if you -- if we're running maybe NIH budgets or something else for a flow. And sorry, I know that's a lot there, but I promise that would be my last question.

[Patrik Jeanmonod, executive]

So I can start with the reagent rental, which is the easiest one. Yes, we've started offering the program, but it's very, very small. So I wouldn't call it as any significance for us, but it's something that we consider continuing to build going forward. On the margin, the -- so, fairly pleased to see that overall, our service business margin has gone up substantially from actually a year ago or eventually even 2 years ago where it wasn't profitable. So I think we checked the box on the service side kind of nicely. On the product, you're correct, we've seen the more pressure on the gross profit margin and that's really a combination of selling instruments that have -- for -- some slightly lower gross profit margin while at the same time, we are still expecting to continue to see this margin to come back up in the future, just because we are continuing to optimize our business. Finally, on the IPO question earlier this year, obviously, it was a very positive and welcoming trend. I think the one point that we make it the trend, so we will welcome other IPOs and hopefully, that will drive some CapEx. But I'll turn it also to Wenbin if he wants to add anything to my earlier comments.

[Wenbin Jiang, executive]

Yes. Regarding to the product gross margin, as you know, we integrated Luminex Guava products into our portfolio and that product was a low-margin business. However, we have now moved the production completely into our facility -- Cytek facility, and we are expecting to see an improvement on where we were before.

[Operator]

Thank you. One moment for our next question. Our next question comes from Tejas Savant with Morgan Stanley.

[Unknown Analyst]

This is Edmund on for Tejas. First, Patrick, you mentioned modest improvements in customer spending patterns. I was wondering if you guys could provide some more details on that or maybe across end markets or geography? And what are you currently making to your '24 guidance in terms of assumptions for a recovery?

[Patrik Jeanmonod, executive]

Great. So just to go at the different geographies. So what we've seen in Q4 is actually a strength in the EMEA, APAC region and slightly followed by the U.S. or the United States segment. So overall, I think the 2 segments that have driven some growth for us are really APAC and EMEA. Overall, when we look at the split for revenue, we still see 50-plus in that United State region, followed by the EMEA around 28% and then behind that APAC and other for the remaining balance. When looking at the growth for this year, and obviously, we are obviously also in this situation where we're waiting for some macro events to help us a little bit. That could be a bit bad, but overall, I think what we've seen so far is that there's been some activity with key customers. We see demand, we see demand for the sales order, obviously, better we -- especially for this year, I think the expectation in the second half is going to be as pronounced, if not slightly more pronounced than last year.

[Unknown Analyst]

Got it. And appreciating that you guys aren't breaking out contributions from FCI going forward. But with all of your integration action completed, can we expect FCI revenues in 2023 to be a baseline level and for it to grow year-over-year in 2024?

[Patrik Jeanmonod, executive]

That's the expectation, yes.

[Unknown Analyst]

Great. And finally, I think some of the larger tools peers have talked about seeing or expecting a modestly later pharma budget release in 2024. Is this a dynamic that you're seeing as well?

[Patrik Jeanmonod, executive]

I'll turn it to Wenbin.

[Wenbin Jiang, executive]

Absolutely, that's exactly what we are expecting a reason why we have indicated and we are going to see a stronger half in the second half of '24. That's all embedded in our guidance.

[Operator]

Thank you. One moment for our next question. Our next question comes from Jack Wilankisa with TD Cowen.

[Unknown Analyst]

This is Jackie Kisa on the call for Stephen Ma. Just to drill down a bit more on your comments regarding your global footprint. How much does China make up of your APAC revenues? And do you expect 2024 to stabilize with regards to China-based headwinds?

[Patrik Jeanmonod, executive]

Yes. So the majority of APAC have slowly become China. So it's growing.

[Unknown Analyst]

Great. And just a follow-up on that. Could you provide any insight on any exposure you might have to China-based companies which have been recently flagged in the proposed Biosecure Act, such as WuXi AppTec and WuXi Biologics?

[Wenbin Jiang, executive]

And that's more related to genomics and we are a cell analysis company. And so for now, we don't see any real impact.

[Unknown Analyst]

Excellent. And if I could just fit one more in. With regards to your clinical efforts across the globe, are there any specific clinical milestones we could expect to see this coming year?

[Wenbin Jiang, executive]

And as you can see last year, we received IDTR and with this clearance in Europe we expect to see some obvious progress this year on the clinical side for our business over there.

[Operator]

Thank you. One moment for our next question. Our next question comes from Mason Carrico with Stephens.

[Unknown Analyst]

This is Jacob on for Mason. So on your newly launched Orion reagent cocktail mixer that you launched in the fourth quarter. Just wondering what initial customer interest and adoption has been in that and as much as you're willing, how much you're kind of expecting that to contribute in terms of revenue in 2024?

[Patrik Jeanmonod, executive]

Yes. I can take maybe the contribution to the revenue. We don't really break out influence in revenue, but I'll let Wenbin talk to the interest -- customer interest.

[Wenbin Jiang, executive]

Yes. This product was primarily aimed for a pharmaceutical company and the CRO to help them on their clinical studies -- clinical side. And so this is our initial customers and since it was just launched, we are engaging with them and working on it and nail down the interest level, and we expect this is going to be a gradually growing business for us.

[Unknown Analyst]

Got it. Understood. And I know you guys aren't really breaking out your revenue or anything, but I guess just with respect to your reagents business, I know historically it's been a mid- to high single-digit percentage of your total revenue, just wondering in 2024 if that's still -- you still largely hold that expectation or if you see anything, any trends there changing?

[Patrik Jeanmonod, executive]

Yes, all the same expectation with maybe slight improvement over that, yes.

[Unknown Analyst]

Got it. And then just my last one here. Just how do you see OpEx turned in throughout 2024? And that's my last one.

[Patrik Jeanmonod, executive]

Yes. So -- and I'm sure you'll see that in the filing, but this quarter, actually, we landed at $32.8 million in OpEx, and that's the lowest it's been this year. And the expectation is that going forward, we'll manage around this number quite tightly.

[Operator]

Thank you. I'm showing no further questions at this time. Thank you for your participation in today's conference. This concludes the program. You may now disconnect.