Epizyme Inc
F:EPE
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Fundamental Analysis
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![](https://ik.imagekit.io/kkbzr2uz4cp/other/ai-assistant.png)
Epizyme Inc. is a pioneering biopharmaceutical company focused on developing innovative therapies to treat cancer and other serious diseases through the modulation of epigenetics. Founded in 2008, Epizyme has positioned itself at the forefront of this burgeoning field, leveraging its unique expertise in the study of gene expression regulation. The company’s leading product candidate, tazemetostat, has shown promise in clinical trials for treating various forms of solid tumors, including epithelioid sarcoma and certain types of non-Hodgkin lymphoma. With a strong pipeline of investigational drugs that target specific genetic mutations, Epizyme aims to provide personalized treatment options th...
Epizyme Inc. is a pioneering biopharmaceutical company focused on developing innovative therapies to treat cancer and other serious diseases through the modulation of epigenetics. Founded in 2008, Epizyme has positioned itself at the forefront of this burgeoning field, leveraging its unique expertise in the study of gene expression regulation. The company’s leading product candidate, tazemetostat, has shown promise in clinical trials for treating various forms of solid tumors, including epithelioid sarcoma and certain types of non-Hodgkin lymphoma. With a strong pipeline of investigational drugs that target specific genetic mutations, Epizyme aims to provide personalized treatment options that address the underlying causes of disease, which sets it apart in a competitive marketplace.
Investors should take note of Epizyme's strategic partnerships and collaborations that enhance its research capabilities and commercial reach. The company has garnered significant attention on Wall Street and among healthcare professionals, particularly after the FDA's accelerated approval of tazemetostat, signaling a shift in how targeted therapies can transform treatment paradigms in oncology. As Epizyme continues to expand its portfolio and advance its clinical trials, it stands to benefit from the growing demand for innovative cancer therapies. With a commitment to scientific excellence and a vision for transforming patient care, Epizyme Inc. is not just a biotech firm—it's a potential leader in the next era of cancer treatment, making it a compelling consideration for investors looking for opportunities in the healthcare sector.
Epizyme, Inc. is a biopharmaceutical company focused on developing innovative therapies for cancer and other serious diseases. The company primarily operates in the following core business segments:
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Oncology: Epizyme is known for its work in developing targeted therapies for cancer, particularly those that address specific genetic and epigenetic drivers of tumors. Their lead product candidates often focus on utilizing small molecule drugs that target specific histone methyltransferases (HMTs) involved in cancer progression.
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Research and Development: A significant portion of Epizyme's operations is dedicated to R&D. This includes discovering and developing new drug candidates, as well as conducting clinical trials to test their efficacy and safety. The company invests heavily in the preclinical and clinical stages of drug development to advance its pipeline.
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Collaboration and Partnerships: Epizyme has engaged in strategic collaborations with other pharmaceutical and biotechnology companies. These partnerships often involve co-development agreements or licensing arrangements aimed at leveraging complementary expertise and resources.
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Commercial Operations: As Epizyme advances its drug candidates towards commercialization, it forms a segment focused on marketing and sales strategies for their products. This includes preparing for product launches and establishing sales networks to support their FDA-approved therapies.
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Regulatory Affairs: Navigating the regulatory landscape is crucial for biopharmaceutical firms. Epizyme has a segment dedicated to ensuring compliance with all regulatory requirements related to drug development, approval, and post-market surveillance.
These segments collectively support Epizyme's mission of developing novel therapies for patients with unmet medical needs, especially in oncology. Their business strategy emphasizes a strong focus on precision medicine and targeted therapies that can make a meaningful impact on patient outcomes.
Epizyme Inc. (now part of Ipsen) focused on epigenetics-based therapies, particularly in oncology. While specifics may change over time and vary based on market dynamics, historically, several competitive advantages could have been attributed to Epizyme:
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Specialized Expertise in Epigenetics: Epizyme leveraged its deep understanding of epigenetic regulation, which is increasingly recognized as crucial in cancer therapeutics. This specialization can set the company apart from competitors focusing on more traditional targets.
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Innovative Drug Pipeline: Epizyme developed a pipeline of targeted therapies that address unmet medical needs, particularly in rare and difficult-to-treat cancers. This focus on niche markets can lead to less competition and higher barriers to entry for other firms.
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Partnerships and Collaborations: Strategic alliances, such as partnerships with larger pharmaceutical companies, can provide Epizyme with access to additional resources, funding, and expertise for drug development and commercialization.
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Regulatory Advantages: Fast Track or Orphan Drug designations from regulatory agencies can accelerate development timelines and provide financial benefits, resulting in competitive edges over rivals who may not have such designations.
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Data-Driven Approaches: Utilizing biomarker-driven patient selection allows for more precise targeting of therapies, potentially improving outcomes and positioning the company favorably in the eyes of healthcare providers and patients.
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Early Clinical Success: Positive clinical trial results can lead to stronger market positioning and increased investor confidence, giving Epizyme an edge when competing for market share and funding.
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Intellectual Property Portfolio: A strong patent portfolio can protect key innovations and create barriers to entry for competitors, ensuring that Epizyme retains a competitive advantage in specific therapeutic areas.
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Patient-Centric Focus: A strong commitment to patient advocacy and education can enhance brand loyalty and differentiation in a crowded market.
In conclusion, Epizyme’s advantages stemmed from its specialized knowledge, innovative approach, strategic partnerships, and a focus on niche markets, culminating in a competitive position within the biopharmaceutical landscape, particularly concerning epigenetic therapies.
Epizyme Inc, like many biotechnology companies, faces several risks and challenges that could impact its operations and financial performance in the near future. Here are some key areas to consider:
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Regulatory Risks: The biotechnology industry is subject to stringent regulations and requirements from agencies like the FDA. Any delays or issues in the approval process for new drugs could adversely affect Epizyme’s market position and financial health.
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Clinical Development Risks: The success of Epizyme relies heavily on the outcomes of clinical trials. There is always a risk that clinical trials may fail or yield inconclusive results, which can lead to substantial financial losses and affect investor confidence.
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Market Competition: The biotechnology sector is highly competitive, with many companies developing similar therapies. New competitors or advancements in treatment could render Epizyme’s products less desirable or obsolete.
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Funding and Financial Stability: Drug development is capital-intensive, and Epizyme may face challenges in securing adequate funding. Dependence on external financing can impact operational flexibility and growth prospects.
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Intellectual Property Issues: Protecting intellectual property is crucial in the biotech industry. Any challenges related to patents or intellectual property rights can adversely affect product development and market exclusivity.
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Market Adoption and Sales Risks: Even with successful clinical results and regulatory approval, there is no guarantee that healthcare providers and patients will adopt Epizyme’s products. Market acceptance is critical for commercial success.
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Economic Factors: Broader economic conditions, including changes in healthcare policies, pricing pressures, and reimbursement rates, can affect the company's profitability and operational environment.
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Technological Changes: Rapid advancements in technology and medical science can change the landscape of drug development and treatment options, requiring companies like Epizyme to adapt quickly or risk falling behind.
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Management and Operational Risks: The success of a biotechnology company often hinges on its leadership and operational execution. Any missteps in strategy or management decisions can result in setbacks.
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Supply Chain Disruptions: As seen in recent global events, companies may face supply chain disruptions that can delay product development or increase costs.
In summary, Epizyme Inc will need to navigate these risks carefully while executing its business strategy to thrive in the competitive biotech landscape. Ensuring effective risk management and maintaining flexibility in operations will be essential for overcoming these challenges.
Revenue & Expenses Breakdown
Epizyme Inc
Balance Sheet Decomposition
Epizyme Inc
Current Assets | 186.8m |
Cash & Short-Term Investments | 144.4m |
Receivables | 11.2m |
Other Current Assets | 31.2m |
Non-Current Assets | 77.3m |
PP&E | 19.2m |
Intangibles | 40.8m |
Other Non-Current Assets | 17.4m |
Current Liabilities | 35m |
Accounts Payable | 5m |
Accrued Liabilities | 30m |
Non-Current Liabilities | 249.5m |
Long-Term Debt | 232.9m |
Other Non-Current Liabilities | 16.6m |
Earnings Waterfall
Epizyme Inc
Revenue
|
53m
USD
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Cost of Revenue
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-13m
USD
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Gross Profit
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40.1m
USD
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Operating Expenses
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-236.2m
USD
|
Operating Income
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-196.2m
USD
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Other Expenses
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-11.6m
USD
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Net Income
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-207.7m
USD
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Free Cash Flow Analysis
Epizyme Inc
USD | |
Free Cash Flow | USD |
EPE Profitability Score
Profitability Due Diligence
Epizyme Inc's profitability score is 27/100. The higher the profitability score, the more profitable the company is.
Score
Epizyme Inc's profitability score is 27/100. The higher the profitability score, the more profitable the company is.
EPE Solvency Score
Solvency Due Diligence
Epizyme Inc's solvency score is 42/100. The higher the solvency score, the more solvent the company is.
Score
Epizyme Inc's solvency score is 42/100. The higher the solvency score, the more solvent the company is.
Wall St
Price Targets
EPE Price Targets Summary
Epizyme Inc
Shareholder Yield
Current shareholder yield for EPE is .
Shareholder yield represents the total return a company provides to its shareholders, calculated as the sum of dividend yield, buyback yield, and debt paydown yield. What is shareholder yield?
EPE Price
Epizyme Inc
Average Annual Return | -17.13% |
Standard Deviation of Annual Returns | 87.7% |
Max Drawdown | -99% |
Market Capitalization | 94.1B EUR |
Shares Outstanding | 164 875 008 |
Percentage of Shares Shorted |
N/A
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Profile
Country
Industry
Market Cap
Dividend Yield
Description
Epizyme, Inc. is a clinical-stage biopharmaceutical company. The company is headquartered in Cambridge, Massachusetts and currently employs 250 full-time employees. The company went IPO on 2013-05-31. The firm is engaged in the treatment of people with cancer through the discovery, development, and commercialization of epigenetic medicines. The firm's lead product TAZVERIK (tazemetostat) is used for epithelioid sarcoma (ES), and follicular lymphoma (FL). Tazemetostat is an oral, selective small molecule inhibitor of the EZH2 histone methyltransferase (HMT), for the treatment of adult and pediatric patients aged 16 years and older with metastatic or locally advanced ES not eligible for complete resection. The company is developing tazemetostat for lymphomas and B-cell malignancies, including B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), multiple myeloma and others. Its advanced product candidate, EZM0414, is an oral inhibitor of the SETD2 HMT. The firm is assessing the use of tazemetostat for immuno-oncology-sensitive tumors, such as small cell lung cancer, prostate cancer, and others.